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ALDH1A inhibitor 673A
CAS No. 109437-62-9
ALDH1A inhibitor 673A ( ALDH1Ai 673A )
产品货号. M10366 CAS No. 109437-62-9
ALDH1A 抑制剂 673A (ALDH1Ai 673A) 是一种有效的、选择性的泛 ALDH1A 抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7857 | 有现货 |
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| 50MG | ￥16038 | 有现货 |
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| 100MG | ￥20250 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ALDH1A inhibitor 673A
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ALDH1A 抑制剂 673A (ALDH1Ai 673A) 是一种有效的、选择性的泛 ALDH1A 抑制剂。
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产品描述ALDH1A inhibitor 673A (ALDH1Ai 673A) is a potent, selective, pan-ALDH1A inhibitor with IC50 of 246, 230 and 348 nM for ALDH1A1, ALDH1A2 and ALDH1A3, respectively; shows no significant activity against ALDH2 (IC50 14 mM) or numerous other ALDH family members; ALDH1Ai 673A preferentially kills CD133+ ovarian cancer stem-like cells (CSCs), induces necroptotic CSC death, mediated, in part, by the induction of mitochondrial uncoupling proteins (UCPs) and reduction in oxidative phosphorylation; ALDH1Ai 673A is highly synergistic with chemotherapy, reducing tumor initiation capacity and increasing tumor eradication in vivo.
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体外实验——
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体内实验——
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同义词ALDH1Ai 673A
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通路Metabolic Enzyme/Protease
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靶点ALDH
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受体ALDH
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研究领域——
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适应症——
化学信息
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CAS Number109437-62-9
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分子量223.275
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分子式C15H13NO
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纯度>98% (HPLC)
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溶解度——
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SMILESC1C2=CC=CC=C2CN1C3=CC=C(C=C3)C=O
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化学全称4-(isoindolin-2-yl)benzaldehyde
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Chefetz I, et al. Cell Rep. 2019 Mar 12;26(11):3061-3075.e6.
